Epigenetic dysregulation of secreted frizzled-related proteins in myeloproliferative neoplasms complements the JAK2V617F-mutation

BACKGROUND: Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway, which plays a central role in stem cell maintenance and differentiation of stem cells and hematopoietic progenitors. Epigenetic downregulation of SFRPs by promoter hypermethylation has been described...

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Detalhes bibliográficos
Main Authors: Bennemann, Karla, Galm, Oliver, Wilop, Stefan, Schubert, Claudia, Brümmendorf, Tim H, Jost, Edgar
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502569/
https://ncbi.nlm.nih.gov/pubmed/22935201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-4-12
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