Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies

Modulating the binding affinities to IgE or changing the FcγR binding properties of anti-IgE antibodies offers an opportunity to enhance the therapeutic potential of anti-IgE antibodies, but the influence of increased affinity to IgE or reduced Fc effector function on the pharmacological properties...

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Main Authors: Mortensen, Deborah L., Prabhu, Saileta, Stefanich, Eric G., Kadkhodayan-Fischer, Saloumeh, Gelzleichter, Thomas R., Baker, Dana, Jiang, Jenny, Wallace, Kristin, Iyer, Suhasini, Fielder, Paul J., Putnam, Wendy S.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502239/
https://ncbi.nlm.nih.gov/pubmed/23778267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22216
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