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Characterization of antibody variants during process development: The tale of incomplete processing of N-terminal secretion peptide
Monoclonal antibodies (mAbs) have emerged as one of the most important classes of biotherapeutics, although development of these molecules is long and arduous. A production cell line must be established, and growth conditions for the cells and purification processes for the product must be optimized...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3502237/ https://ncbi.nlm.nih.gov/pubmed/22932441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.21614 |
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