Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway.
Cultured human fibroblasts degrade insulin by a receptor-mediated process. When intracellular hormone degradation is inhibited by chloroquine, 125I-labeled insulin internalizes and accumulates intracellularly. In contrast, cultured IM-9 lymphocytes do not degrade receptor-bound insulin or accumulate...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1980
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6108561/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.10.5975 |
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