Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep(ob/ob)-Keap1-knockdown (KD) mice, which have increased Nrf2 activity, were generated. Markers of obesity and type...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Xu, Jialin, Kulkarni, Supriya R., Donepudi, Ajay C., More, Vijay R., Slitt, Angela L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Diabetes Association 2012
Gaiak:
Obesity Studies
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501889/
https://ncbi.nlm.nih.gov/pubmed/22936178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1716
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak