Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep(ob/ob)-Keap1-knockdown (KD) mice, which have increased Nrf2 activity, were generated. Markers of obesity and type...

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Hlavní autoři: Xu, Jialin, Kulkarni, Supriya R., Donepudi, Ajay C., More, Vijay R., Slitt, Angela L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Obesity Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501889/
https://ncbi.nlm.nih.gov/pubmed/22936178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1716
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