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Rapid, Microwave-Assisted Organic Synthesis of Selective (V600E)BRAF Inhibitors for Preclinical Cancer Research

We report a dramatically improved total synthesis of two highly selective (V600E)BRAF inhibitors, PLX4720 and PLX4032, that leverages microwave-assisted organic synthesis (MAOS). Compared with previously reported approaches, our novel MAOS method significantly reduces overall reaction time without c...

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Détails bibliographiques
Auteurs principaux: Buck, Jason R., Saleh, Sam, Uddin, Md. Imam, Manning, H. Charles
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501741/
https://ncbi.nlm.nih.gov/pubmed/23180892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2012.05.137
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