DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

Induction of type I interferons by the bacterial secondary messengers cyclic-di-GMP (c-di-GMP) or cyclic-di-AMP (c-di-AMP) is dependent on a signaling axis involving the STING adaptor, TBK1 kinase and IRF3 transcription factor. Here we identified the helicase DEAD box polypeptide 41 (DDX41) as a pat...

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Autors principals: Parvatiyar, Kislay, Zhang, Zhiqiang, Teles, Rosane M, Ouyang, Songying, Jiang, Yan, Iyer, Shankar S, Zaver, Shivam A, Schenk, Mirjam, Zeng, Shang, Zhong, Wenwan, Liu, Zhi-Jie, Modlin, Robert L, Liu, Yongjun, Cheng, Genhong
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501571/
https://ncbi.nlm.nih.gov/pubmed/23142775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2460
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