The Cytochrome b(5) dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae

Tetrahymena thermophila is a free-living ciliate with no exogenous sterol requirement. However, it can perform several modifications on externally added sterols including desaturation at C5(6), C7(8), and C22(23). Sterol desaturases in Tetrahymena are microsomal enzymes that require Cyt b(5), Cyt b(...

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Bibliografiske detaljer
Main Authors: Poklepovich, Tomas J., Rinaldi, Mauro A., Tomazic, Mariela L., Favale, Nicolas O., Turkewitz, Aaron P., Nudel, Clara B., Nusblat, Alejandro D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501532/
https://ncbi.nlm.nih.gov/pubmed/22982564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2012.08.015
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