Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS

Fused in sarcoma (FUS) is a nuclear protein that carries a proline-tyrosine nuclear localization signal (PY-NLS) and is imported into the nucleus via Transportin (TRN). Defects in nuclear import of FUS have been implicated in neurodegeneration, since mutations in the PY-NLS of FUS cause amyotrophic...

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Detalhes bibliográficos
Main Authors: Dormann, Dorothee, Madl, Tobias, Valori, Chiara F, Bentmann, Eva, Tahirovic, Sabina, Abou-Ajram, Claudia, Kremmer, Elisabeth, Ansorge, Olaf, Mackenzie, Ian R A, Neumann, Manuela, Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501225/
https://ncbi.nlm.nih.gov/pubmed/22968170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.261
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