Neuregulin-4 Is a Survival Factor for Colon Epithelial Cells both in Culture and in Vivo

Expression of the ErbB4 tyrosine kinase is elevated in colonic epithelial cells during inflammatory bowel disease, whereas ErbB4 overexpression in cultured colonocytes blocks TNF-induced apoptosis in a ligand-dependent manner. Together, these observations suggest that ErbB4 induction may be a protec...

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Bibliografiska uppgifter
Huvudupphovsmän: Bernard, Jessica K., McCann, Sean P., Bhardwaj, Vrinda, Washington, Mary K., Frey, Mark R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501086/
https://ncbi.nlm.nih.gov/pubmed/23033483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400846
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