Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

Histone-modifying enzymes play a pivotal role in gene expression and repression. In human, DOT1L (Dot1-like) is the only known histone H3 lysine 79 methyltransferase. hDOT1L is associated with transcriptional activation, but the general mechanism connecting hDOT1L to active transcription remains lar...

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Bibliografske podrobnosti
Main Authors: Kim, Seung-Kyoon, Jung, Inkyung, Lee, Hosuk, Kang, Keunsoo, Kim, Mirang, Jeong, Kwiwan, Kwon, Chang Seob, Han, Yong-Mahn, Kim, Yong Sung, Kim, Dongsup, Lee, Daeyoup
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501035/
https://ncbi.nlm.nih.gov/pubmed/23012353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.384057
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