Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast

Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved in most eukaryotes. Yeast Dot1p lacks a SET domain and does not methylate free histones and thus may have different actions w...

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Vydáno v:Nat Commun
Hlavní autoři: Lee, Soyun, Oh, Seunghee, Jeong, Kwiwan, Jo, Hyelim, Choi, Yoonjung, Seo, Hogyu David, Kim, Minhoo, Choe, Joonho, Kwon, Chang Seob, Lee, Daeyoup
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770421/
https://ncbi.nlm.nih.gov/pubmed/29339748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02759-8
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