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Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast
Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved in most eukaryotes. Yeast Dot1p lacks a SET domain and does not methylate free histones and thus may have different actions w...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770421/ https://ncbi.nlm.nih.gov/pubmed/29339748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02759-8 |
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