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Interplay between Menin and K-Ras in Regulating Lung Adenocarcinoma
MEN1, which encodes the nuclear protein menin, acts as a tumor suppressor in lung cancer and is often inactivated in human primary lung adenocarcinoma. Here, we show that the inactivation of MEN1 is associated with increased DNA methylation at the MEN1 promoter by K-Ras. On one hand, the activated K...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501031/ https://ncbi.nlm.nih.gov/pubmed/23027861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382416 |
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