Interplay between Menin and K-Ras in Regulating Lung Adenocarcinoma

MEN1, which encodes the nuclear protein menin, acts as a tumor suppressor in lung cancer and is often inactivated in human primary lung adenocarcinoma. Here, we show that the inactivation of MEN1 is associated with increased DNA methylation at the MEN1 promoter by K-Ras. On one hand, the activated K...

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Detalhes bibliográficos
Main Authors: Wu, Yuan, Feng, Zi-Jie, Gao, Shu-Bin, Matkar, Smita, Xu, Bin, Duan, Hong-Bin, Lin, Xiao, Li, Shan-Hua, Hua, Xianxin, Jin, Guang-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501031/
https://ncbi.nlm.nih.gov/pubmed/23027861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382416
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