Cutaneous Retinoic Acid Levels Determine Hair Follicle Development and Downgrowth

Retinoic acid (RA) is essential during embryogenesis and for tissue homeostasis, whereas excess RA is well known as a teratogen. In humans, excess RA is associated with hair loss. In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes,...

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Hlavní autoři: Okano, Junko, Levy, Clara, Lichti, Ulrike, Sun, Hong-Wei, Yuspa, Stuart H., Sakai, Yasuo, Morasso, Maria I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501026/
https://ncbi.nlm.nih.gov/pubmed/23007396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397273
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