Pathogenic SYNGAP1 mutations impair cognitive development by disrupting the maturation of dendritic spine synapses

Mutations that cause Intellectual Disability (ID) and Autism Spectrum Disorder (ASD) are commonly found in genes that encode for synaptic proteins. However, it remains unclear how mutations that disrupt synapse function impact intellectual ability. In the SYNGAP1 mouse model of ID/ASD, we found that...

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Xehetasun bibliografikoak
Egile Nagusiak: Clement, James P., Aceti, Massimiliano, Creson, Thomas K., Ozkan, Emin D., Shi, Yulin, Reish, Nicholas J., Almonte, Antoine G., Miller, Brooke H., Wiltgen, Brian J., Miller, Courtney A., Xu, Xiangmin, Rumbaugh, Gavin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500766/
https://ncbi.nlm.nih.gov/pubmed/23141534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.08.045
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