Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons

Syngap1 haploinsufficiency is a common cause of sporadic intellectual disability. Syngap1 mutations disrupt developing pyramidal neurons, though it remains unclear if this process contributes to cognitive abnormalities. Here, we found that haploinsufficiency restricted to forebrain glutamatergic neu...

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Detalhes bibliográficos
Main Authors: Ozkan, Emin D., Creson, Thomas K., Kramár, Enikö A., Rojas, Camilo, Seese, Ron R., Babyan, Alex H., Shi, Yulin, Lucero, Rocco, Xu, Xiangmin, Noebels, Jeffrey L., Miller, Courtney A., Lynch, Gary, Rumbaugh, Gavin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104574/
https://ncbi.nlm.nih.gov/pubmed/24945774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.05.015
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