The BH3-only proteins Bim and Puma cooperate to impose deletional T-cell tolerance to organ-specific antigens

Although the pro-apoptotic BH3-only protein, Bim, is required for deletion of autoreactive thymocytes, Bim-deficient mice do not succumb to extensive organ-specific autoimmune disease. To determine whether other BH3-only proteins safeguard tolerance in the absence of Bim, we screened mice lacking Bi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gray, Daniel H. D., Kupresanin, Fiona, Berzins, Stuart P., Herold, Marco J., O’Reilly, Lorraine A., Bouillet, Philippe, Strasser, Andreas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500635/
https://ncbi.nlm.nih.gov/pubmed/22960223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.05.030
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak