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The BH3-only proteins Bim and Puma cooperate to impose deletional T-cell tolerance to organ-specific antigens
Although the pro-apoptotic BH3-only protein, Bim, is required for deletion of autoreactive thymocytes, Bim-deficient mice do not succumb to extensive organ-specific autoimmune disease. To determine whether other BH3-only proteins safeguard tolerance in the absence of Bim, we screened mice lacking Bi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500635/ https://ncbi.nlm.nih.gov/pubmed/22960223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.05.030 |
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