The BH3-only proteins Bim and Puma cooperate to impose deletional T-cell tolerance to organ-specific antigens

Although the pro-apoptotic BH3-only protein, Bim, is required for deletion of autoreactive thymocytes, Bim-deficient mice do not succumb to extensive organ-specific autoimmune disease. To determine whether other BH3-only proteins safeguard tolerance in the absence of Bim, we screened mice lacking Bi...

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Autores principales: Gray, Daniel H. D., Kupresanin, Fiona, Berzins, Stuart P., Herold, Marco J., O’Reilly, Lorraine A., Bouillet, Philippe, Strasser, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500635/
https://ncbi.nlm.nih.gov/pubmed/22960223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.05.030
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