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Bioactivation of the Cancer Chemopreventive Agent Tamoxifen to Quinone Methides by Cytochrome P4502B6 and Identification of the Modified Residue on the Apoprotein

The nonsteroidal antiestrogen tamoxifen was introduced as a treatment for breast cancer 3 decades ago. It has also been approved as a chemopreventive agent and is prescribed to women at high risk for this disease. However, several studies have shown that use of tamoxifen leads to increased risk of e...

詳細記述

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書誌詳細
主要な著者: Sridar, Chitra, D'Agostino, Jaime, Hollenberg, Paul F.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500549/
https://ncbi.nlm.nih.gov/pubmed/22942317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.047266
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