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Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?
The formation of quinone methides (QMs) from either direct 2-electron oxidation of 2- or 4-alkylphenols, isomerization of o-quinones, or elimination of a good leaving group could explain the cytotoxic/cytoprotective effects of several drugs, natural products, as well as endogenous compounds. For exa...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4204646/ https://ncbi.nlm.nih.gov/pubmed/25346613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/138527281801140121123046 |
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