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Bioactivation of Nevirapine to a Reactive Quinone Methide: Implications for Liver Injury
[Image: see text] Nevirapine (NVP) treatment is associated with a significant incidence of liver injury. We developed an anti-NVP antiserum to determine the presence and pattern of covalent binding of NVP to mouse, rat, and human hepatic tissues. Covalent binding to hepatic microsomes from male C57B...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3475366/ https://ncbi.nlm.nih.gov/pubmed/22793666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300172s |
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