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Crosstalk between ROR1 and the pre-B-Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia
We report that t(1;19)-ALL cells universally exhibit expression of and dependence on the cell surface receptor, ROR1. We further identify t(1;19)-ALL cell sensitivity to the kinase inhibitor dasatinib due to its inhibition of the pre-B-cell receptor (pre-BCR) signaling complex. These phenotypes are...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500515/ https://ncbi.nlm.nih.gov/pubmed/23153538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.08.027 |
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