Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long Term Survivors

PURPOSE: Genetic alterations of KRAS, CDKN2A, TP53 and SMAD4 are the most frequent events in pancreatic cancer. We determined the extent to which these four alterations are coexistent in the same carcinoma, and their impact on patient outcome. EXPERIMENTAL DESIGN: Pancreatic cancer patients who unde...

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Detalhes bibliográficos
Main Authors: Yachida, Shinichi, White, Catherine M., Naito, Yoshiki, Zhong, Yi, Brosnan, Jacqueline A., Macgregor-Das, Anne M., Morgan, Richard A., Saunders, Tyler, Laheru, Daniel A., Herman, Joseph M., Hruban, Ralph H., Klein, Alison P., Jones, Siân, Velculescu, Victor, Wolfgang, Christopher L., Iacobuzio-Donahue, Christine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500447/
https://ncbi.nlm.nih.gov/pubmed/22991414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1215
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