Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long Term Survivors

PURPOSE: Genetic alterations of KRAS, CDKN2A, TP53 and SMAD4 are the most frequent events in pancreatic cancer. We determined the extent to which these four alterations are coexistent in the same carcinoma, and their impact on patient outcome. EXPERIMENTAL DESIGN: Pancreatic cancer patients who unde...

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Main Authors: Yachida, Shinichi, White, Catherine M., Naito, Yoshiki, Zhong, Yi, Brosnan, Jacqueline A., Macgregor-Das, Anne M., Morgan, Richard A., Saunders, Tyler, Laheru, Daniel A., Herman, Joseph M., Hruban, Ralph H., Klein, Alison P., Jones, Siân, Velculescu, Victor, Wolfgang, Christopher L., Iacobuzio-Donahue, Christine A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500447/
https://ncbi.nlm.nih.gov/pubmed/22991414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1215
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