Tyr682 in the APP intracellular domain regulates synaptic connectivity, cholinergic function and cognitive performance

Processing of Aβ-precursor protein (APP) plays an important role in Alzheimer’s disease (AD) pathogenesis. The APP intracellular domain contains residues important in regulating APP function and processing, in particular the (682)YENPTY(687) motif. To dissect the functions of this sequence in vivo,...

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Autores principales: Matrone, Carmela, Luvisetto, Siro, La Rosa, Luca R., Tamayev, Robert, Pignataro, Annabella, Canu, Nadia, Yang, Li, Barbagallo, Alessia P. M., Biundo, Fabrizio, Lombino, Franco, Zheng, Hui, Ammassari-Teule, Martine, D’Adamio, Luciano
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500432/
https://ncbi.nlm.nih.gov/pubmed/23020178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12009
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