Tyr682 in the APP intracellular domain regulates synaptic connectivity, cholinergic function and cognitive performance

Processing of Aβ-precursor protein (APP) plays an important role in Alzheimer’s disease (AD) pathogenesis. The APP intracellular domain contains residues important in regulating APP function and processing, in particular the (682)YENPTY(687) motif. To dissect the functions of this sequence in vivo,...

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Detaylı Bibliyografya
Asıl Yazarlar: Matrone, Carmela, Luvisetto, Siro, La Rosa, Luca R., Tamayev, Robert, Pignataro, Annabella, Canu, Nadia, Yang, Li, Barbagallo, Alessia P. M., Biundo, Fabrizio, Lombino, Franco, Zheng, Hui, Ammassari-Teule, Martine, D’Adamio, Luciano
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500432/
https://ncbi.nlm.nih.gov/pubmed/23020178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12009
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