Tyr682 in the APP intracellular domain regulates synaptic connectivity, cholinergic function and cognitive performance

Processing of Aβ-precursor protein (APP) plays an important role in Alzheimer’s disease (AD) pathogenesis. The APP intracellular domain contains residues important in regulating APP function and processing, in particular the (682)YENPTY(687) motif. To dissect the functions of this sequence in vivo,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Matrone, Carmela, Luvisetto, Siro, La Rosa, Luca R., Tamayev, Robert, Pignataro, Annabella, Canu, Nadia, Yang, Li, Barbagallo, Alessia P. M., Biundo, Fabrizio, Lombino, Franco, Zheng, Hui, Ammassari-Teule, Martine, D’Adamio, Luciano
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500432/
https://ncbi.nlm.nih.gov/pubmed/23020178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12009
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