Tyr682 in the APP intracellular domain regulates synaptic connectivity, cholinergic function and cognitive performance

Processing of Aβ-precursor protein (APP) plays an important role in Alzheimer’s disease (AD) pathogenesis. The APP intracellular domain contains residues important in regulating APP function and processing, in particular the (682)YENPTY(687) motif. To dissect the functions of this sequence in vivo,...

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Autors principals: Matrone, Carmela, Luvisetto, Siro, La Rosa, Luca R., Tamayev, Robert, Pignataro, Annabella, Canu, Nadia, Yang, Li, Barbagallo, Alessia P. M., Biundo, Fabrizio, Lombino, Franco, Zheng, Hui, Ammassari-Teule, Martine, D’Adamio, Luciano
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500432/
https://ncbi.nlm.nih.gov/pubmed/23020178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12009
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