Metformin Reduces Hepatic Expression of SIRT3, the Mitochondrial Deacetylase Controlling Energy Metabolism

Metformin inhibits ATP production in mitochondria and this may be involved in the anti-hyperglycemic effects of the drug. Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase that regulates the function of the electron transport chain and maintains basal ATP yield. We hypothesized that metformin...

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Bibliografiska uppgifter
Huvudupphovsmän: Buler, Marcin, Aatsinki, Sanna-Mari, Izzi, Valerio, Hakkola, Jukka
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500349/
https://ncbi.nlm.nih.gov/pubmed/23166782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049863
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