The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility

Amorphous solid dispersions (ASDs) are a promising formulation approach for poorly soluble active pharmaceutical ingredients (APIs), because they ideally enhance both dissolution rate and solubility. However, the mechanism behind this is not understood in detail. In the present study, we investigate...

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Bibliographic Details
Main Authors: Frank, Kerstin J, Westedt, Ulrich, Rosenblatt, Karin M, Hölig, Peter, Rosenberg, Jörg, Mägerlein, Markus, Fricker, Gert, Brandl, Martin
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2012
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500034/
https://ncbi.nlm.nih.gov/pubmed/23166440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S36571
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