The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility

Amorphous solid dispersions (ASDs) are a promising formulation approach for poorly soluble active pharmaceutical ingredients (APIs), because they ideally enhance both dissolution rate and solubility. However, the mechanism behind this is not understood in detail. In the present study, we investigate...

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Main Authors: Frank, Kerstin J, Westedt, Ulrich, Rosenblatt, Karin M, Hölig, Peter, Rosenberg, Jörg, Mägerlein, Markus, Fricker, Gert, Brandl, Martin
格式: Artigo
語言:Inglês
出版: Dove Medical Press 2012
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500034/
https://ncbi.nlm.nih.gov/pubmed/23166440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S36571
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