Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition

Oligonucleotide aptamer-mediated in vivo cell targeting of small interfering RNAs (siRNAs) is emerging as a useful approach to enhance the efficacy and reduce the adverse effects resulting from siRNA-mediated genetic interference. A current main impediment in aptamer-mediated siRNA targeting is that...

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Bibliografski detalji
Glavni autori: Berezhnoy, Alexey, Brenneman, Randall, Bajgelman, Marcio, Seales, Dawn, Gilboa, Eli
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499696/
https://ncbi.nlm.nih.gov/pubmed/23344651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.41
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