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Identification of HIV-1 Inhibitors Targeting The Nucleocapsid Protein

The HIV-1 nucleocapsid (NC) is a RNA/DNA binding protein encoded within the Gag polyprotein, which is critical for the selection and chaperoning of viral genomic RNA during virion assembly. RNA/DNA binding occurs through a highly conserved zinc-knuckle motif present in NC. Given the necessity of NC-...

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Detalhes bibliográficos
Main Authors: Breuer, Sebastian, Chang, Max W., Yuan, Jinyun, Torbett, Bruce E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499629/
https://ncbi.nlm.nih.gov/pubmed/22587465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201442t
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