A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis

BACKGROUND: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that is caused by the expansion of a polyglutamine (polyQ) stretch within Huntingtin (htt), the protein product of the HD gene. Although studies in vitro have suggested that the mutant htt can act in a potential...

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Autors principals: Zheng, Shuqiu, Ghitani, Nima, Blackburn, Jessica S, Liu, Jeh-Ping, Zeitlin, Scott O
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499431/
https://ncbi.nlm.nih.gov/pubmed/22892315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-5-28
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