Pharmacokinetics of engineered human monomeric and dimeric CH2 domains

Therapeutic monoclonal antibodies have several advantages over small molecule drugs and small proteins and peptides, including a long serum half-life. The long serum half-life of IgG is due, in part, to its molecular weight (150kDa) and its ability to bind FcRn. Both the CH2 and CH3 domains of Fc ar...

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Détails bibliographiques
Auteurs principaux: Gehlsen, Kurt R., Gong, Rui, Bramhill, Dave, Wiersma, David A., Kirkpatrick, Shaun A., Wang, Yangping, Feng, Yang, Dimitrov, Dimiter S.
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499341/
https://ncbi.nlm.nih.gov/pubmed/22699277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.20652
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