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Engineered antibody CH2 domains binding to nucleolin: Isolation, characterization and improvement of aggregation

Smaller recombinant antibody fragments are now emerging as alternatives of conventional antibodies. Especially, immunoglobulin (Ig) constant CH2 domain and engineered CH2 with improved stability are promising as scaffolds for selection of specific binders to various antigens. We constructed a yeast...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Li, Dezhi, Gong, Rui, Zheng, Jun, Chen, Xihai, Dimitrov, Dimiter S., Zhao, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957259/
https://ncbi.nlm.nih.gov/pubmed/28202413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.02.058
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