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Total Synthesis of the Galbulimima Alkaloid (−)-GB17

The first enantioselective total synthesis of (−)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions. The first of these Michael additions is controlled by the use of a chiral organocatalyst, while the seco...

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Detalhes bibliográficos
Main Authors: Larson, Reed T., Clift, Michael D., Thomson, Regan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498908/
https://ncbi.nlm.nih.gov/pubmed/22287499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201108227
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