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Sirtuin-4 Modulates Sensitivity to Induction of the Mitochondrial Permeability Transition Pore

The sustained opening of the mitochondrial permeability transition pore (PTP) is a decisive event in the onset of irreversible cell injury. The PTP is modulated by numerous exogenous and endogenous effectors, including mitochondrial membrane potential, ions and metabolites. Mitochondrial sirtuins ha...

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Autors principals: Verma, Manish, Shulga, Nataly, Pastorino, John G.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498821/
https://ncbi.nlm.nih.gov/pubmed/23044393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2012.09.016
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