Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication

The interaction between the human immunodeficiency virus (HIV) integrase (IN) and its cellular cofactor lens epithelium-derived growth factor (LEDGF/p75) is crucial for HIV replication. While recently discovered LEDGINs inhibit HIV-1 replication by occupying the LEDGF/p75 pocket in IN, it remained t...

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Autori principali: Desimmie, Belete A, Humbert, Michael, Lescrinier, Eveline, Hendrix, Jelle, Vets, Sofie, Gijsbers, Rik, Ruprecht, Ruth M, Dietrich, Ursula, Debyser, Zeger, Christ, Frauke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498793/
https://ncbi.nlm.nih.gov/pubmed/22828501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.132
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