Hepatocyte - Stellate Cell Crosstalk in the Liver Engenders a Permissive Inflammatory Microenvironment that Drives Progression in Hepatocellular Carcinoma

Many solid malignant tumors arise on a background of inflamed and/or fibrotic tissues, features which are found in more than 80% hepatocellular carcinomas (HCC). Activated hepatic stellate cells (HSC) play a critical role in fibrogenesis associated with HCC onset and progression, yet their functiona...

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Autori principali: Coulouarn, Cédric, Corlu, Anne, Glaise, Denise, Guenon, Isabelle, Thorgeirsson, Snorri S., Clement, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498759/
https://ncbi.nlm.nih.gov/pubmed/22419664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3317
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