UGT1A9, UGT2B7 and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients

BACKGROUND: Mycophenolic acid (MPA) exposure in pediatric kidney transplant patients receiving body surface area (BSA)-based dosing exhibits large variability. Several genetic variants in glucuronosyl transferases (UGTs) and of multidrug resistance-associated protein 2 (MRP2) have independently been...

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Bibliographische Detailangaben
Hauptverfasser: Fukuda, Tsuyoshi, Goebel, Jens, Cox, Shareen, Maseck, Denise, Zhang, Kejian, Sherbotie, Joseph R., Ellis, Eileen N., James, Laura P., Ward, Robert M., Vinks, Alexander A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498586/
https://ncbi.nlm.nih.gov/pubmed/23131697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e3182708f84
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