PHARMACOKINETICS AND PHARMACODYNAMICS OF MYCOPHENOLIC ACID AND THEIR RELATION TO RESPONSE TO THERAPY OF CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS

BACKGROUND: Mycophenolic acid (MPA) is the active form of mycophenolate mofetil (MMF) which is currently used off-label as immunosuppressive therapy in childhood-onset SLE (cSLE). The objectives of this study were to (1) characterize the pharmacokinetics (MPA-PK) and pharmacodynamics (MPA-PD) of MPA...

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Main Authors: Sagcal-Gironella, Anna Carmela P., Fukuda, Tsuyoshi, Wiers, Kristina, Cox, Shareen, Nelson, Shannen, Dina, Blair, Sherwin, Catherine M.T., Klein-Gitelman, Marisa S., Vinks, Alexander A., Brunner, Hermine I.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021770/
https://ncbi.nlm.nih.gov/pubmed/20655577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semarthrit.2010.05.007
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