Molecular Evolution and Structural Features of IRAK Family Members

The interleukin-1 receptor-associated kinase (IRAK) family comprises critical signaling mediators of the TLR/IL-1R signaling pathways. IRAKs are Ser/Thr kinases. There are 4 members in the vertebrate genome (IRAK1, IRAK2, IRAKM, and IRAK4) and an IRAK homolog, Pelle, in insects. IRAK family members...

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Bibliographic Details
Main Authors: Gosu, Vijayakumar, Basith, Shaherin, Durai, Prasannavenkatesh, Choi, Sangdun
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498205/
https://ncbi.nlm.nih.gov/pubmed/23166766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049771
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