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Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia.

Nucleated bone marrow cells from normal individuals and from three patients with homozygous beta+-thalassemia were pulse-labeled with tritiated nucleosides. The processing of the newly synthesized globin mRNA precursors was monitored by inhibiting additional transcription with actinomycin D for 30 m...

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Bibliografiske detaljer
Main Authors: Maquat, L E, Kinniburgh, A J, Beach, L R, Honig, G R, Lazerson, J, Ershler, W B, Ross, J
Format: Artigo
Sprog:Inglês
Udgivet: 1980
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC349818/
https://ncbi.nlm.nih.gov/pubmed/6933479
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