Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia.

Nucleated bone marrow cells from normal individuals and from three patients with homozygous beta+-thalassemia were pulse-labeled with tritiated nucleosides. The processing of the newly synthesized globin mRNA precursors was monitored by inhibiting additional transcription with actinomycin D for 30 m...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Maquat, L E, Kinniburgh, A J, Beach, L R, Honig, G R, Lazerson, J, Ershler, W B, Ross, J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349818/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6933479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.7.4287
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