High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD(+) and in complex with NAD(+) and triclosan

Enoyl-acyl carrier protein reductase (ENR; the product of the fabI gene) is an important enzyme that is involved in the type II fatty-acid-synthesis pathway of bacteria, plants, apicomplexan protozoa and mitochondria. Harmful pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum use...

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Détails bibliographiques
Auteurs principaux: Otero, José M., Noël, Ann-Josée, Guardado-Calvo, Pablo, Llamas-Saiz, Antonio L., Wende, Wolfgang, Schierling, Benno, Pingoud, Alfred, van Raaij, Mark J.
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2012
Sujets:
Structural Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497968/
https://ncbi.nlm.nih.gov/pubmed/23027736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112033982
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