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Protein folding kinetics and thermodynamics from atomistic simulation

Advances in simulation techniques and computing hardware have created a substantial overlap between the timescales accessible to atomic-level simulations and those on which the fastest-folding proteins fold. Here we demonstrate, using simulations of four variants of the human villin headpiece, how s...

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Autors principals: Piana, Stefano, Lindorff-Larsen, Kresten, Shaw, David E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497772/
https://ncbi.nlm.nih.gov/pubmed/22822217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201811109
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