Functional Redundancy in HIV-1 Viral Particle Assembly

Expression of a retroviral Gag protein in mammalian cells leads to the assembly of virus particles. In vitro, recombinant Gag proteins are soluble but assemble into virus-like particles (VLPs) upon addition of nucleic acid. We have proposed that Gag undergoes a conformational change when it is at a...

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Bibliographic Details
Main Authors: O'Carroll, Ina P., Crist, Rachael M., Mirro, Jane, Harvin, Demetria, Soheilian, Ferri, Kamata, Anne, Nagashima, Kunio, Rein, Alan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497692/
https://ncbi.nlm.nih.gov/pubmed/22993163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06287-11
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