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Activating KIR Copy Number Variation Is Associated with Granzyme B Release by NK Cells during Primary Simian Immunodeficiency Virus Infection in Rhesus Monkeys

Here we show that the number of activating killer cell immunoglobulin-like receptor (KIR) copies in rhesus monkeys is associated with the extent of release of cytotoxic granules by cytolytic NK cells during primary simian immunodeficiency virus SIVmac251 infection. These findings suggest that NK cel...

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Bibliografiske detaljer
Main Authors: Hellmann, Ina, Schmitz, Jörn E., Letvin, Norman L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497682/
https://ncbi.nlm.nih.gov/pubmed/23015705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00325-12
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