Impaired Innate Immunity in Mice Deficient in Interleukin-1 Receptor-Associated Kinase 4 Leads to Defective Type 1 T Cell Responses, B Cell Expansion, and Enhanced Susceptibility to Infection with Toxoplasma gondii

Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a member of the IRAK family and has an important role in inducing the production of inflammatory mediators. This kinase is downstream of MyD88, an adaptor protein essential for Toll-like receptor (TLR) function. We investigated the role of...

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Autores principales: Béla, Samantha R., Dutra, Míriam S., Mui, Ernest, Montpetit, Alexandre, Oliveira, Fernanda S., Oliveira, Sérgio C., Arantes, Rosa M. E., Antonelli, Lis R., McLeod, Rima, Gazzinelli, Ricardo T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497418/
https://ncbi.nlm.nih.gov/pubmed/23027530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00328-12
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